LYST-AS1

Across TCGA pan-cancer cohorts, LYST-AS1 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of LYST-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where LYST-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LYST-AS1 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

KIRC, HNSC, and KIRP are the cancer types where LYST-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LYST-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	All	+0.115	<.001	3	view →
HNSC	Female	III,IV	+0.160	.014	2	view →
KIRP	All	III,IV	+0.142	.044	2	view →
THCA	Female	II,III,IV	−0.161	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

LYST-AS1–KIRC

Open the KIRC breakdown →