LYSMD1

Across TCGA cell cohorts, LYSMD1 mutation is significantly associated with the mutation status of many other genes, with 382 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LYSMD1-associated genes across cancer lineages are CDC73, PITPNM1, and PRSS16. Each is linked with LYSMD1 in more than 2 cancer types. Because this analysis shows association rather than direction, both LYSMD1-to-partner and partner-to-LYSMD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDC73 grouped by LYSMD1-low versus LYSMD1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LYSMD1→partner) and Y-score (partner→LYSMD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CDC73 →	+4.824	+5.392	.004	.004	1	3
SKIN	PITPNM1 →	+4.239	+5.053	.007	.007	1	2
SKIN	PRSS16 →	+4.239	+5.053	.007	.007	1	2
SKIN	CPXM2 →	+4.239	+5.053	.007	.007	1	2
SKIN	EXOC4 →	+4.824	+5.392	.004	.004	1	2
SKIN	LGR6 →	+4.239	+5.053	.007	.007	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 382 associations by consensus.

CDC73 by LYSMD1 expression — SKIN

Explore this box plot interactively →