LYSMD1

Across TCGA pan-cancer cohorts, LYSMD1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of LYSMD1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where LYSMD1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LYSMD1 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

HNSC, LIHC, and LUAD are the cancer types where LYSMD1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LYSMD1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+0.868	<.001	12	view →
LIHC	Male	All	+1.221	<.001	9	view →
LUAD	Male	All	+1.096	<.001	9	view →
KICH	Female	All	−1.635	<.001	8	view →
THCA	All	All	−0.291	.002	7	view →
LUSC	Female	All	+1.272	<.001	6	view →
BRCA	All	III,IV	+0.805	<.001	6	view →
BLCA	Female	All	+0.741	.009	6	view →
CHOL	All	All	+2.064	<.001	5	view →
KIRC	All	All	+0.216	.003	5	view →
KIRP	Female	II,III,IV	+0.812	.021	2	view →
PAAD	All	All	+0.402	.031	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

LYSMD1–HNSC

Open the HNSC breakdown →