LYRM9

Across TCGA patient cohorts, LYRM9 mutation is significantly associated with the RNA expression of many other genes, with 61 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LYRM9-associated genes across cancer lineages are OPA3, TRIM54, and ZIC5. Each is linked with LYRM9 in more than 1 cancer types. Because this analysis shows association rather than direction, both LYRM9-to-partner and partner-to-LYRM9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OPA3 grouped by LYRM9-low versus LYRM9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LYRM9→partner) and Y-score (partner→LYRM9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	OPA3 →	+0.497	+3.223	.003	.009	3	1
UCEC	TRIM54 →	+1.261	+3.280	<.001	.008	3	1
UCEC	ZIC5 →	+1.337	+3.793	<.001	.001	3	1
UCEC	CIZ1 →	+0.612	+3.210	.004	.009	3	1
UCEC	SREBF2-AS1 →	+0.719	+3.223	<.001	.009	3	1
UCEC	RNU6-1155P →	+0.175	+5.060	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 61 associations by consensus.

OPA3 by LYRM9 expression — UCEC

Explore this box plot interactively →