LYPD3

Across TCGA cell cohorts, LYPD3 mutation is significantly associated with the mutation status of many other genes, with 2,735 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LYPD3-associated genes across cancer lineages are UNC5B, AHRR, and ANGPT4. Each is linked with LYPD3 in more than 3 cancer types. Because this analysis shows association rather than direction, both LYPD3-to-partner and partner-to-LYPD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UNC5B grouped by LYPD3-low versus LYPD3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LYPD3→partner) and Y-score (partner→LYPD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	UNC5B →	+2.865	+4.217	.007	.007	1	4
LUNG_NSCLC_LUAD	AHRR →	+4.187	+5.000	.008	.008	1	3
BLOOD_Leukemia	ANGPT4 →	+4.000	+5.050	.008	.008	1	3
BLOOD_Leukemia	CNOT4 →	+4.321	+5.285	.005	.005	1	3
LUNG_NSCLC_LUAD	KRT71 →	+4.187	+5.000	.008	.008	1	3
LUNG_NSCLC_LUAD	PALM2AKAP2 →	+5.772	+5.772	.002	.002	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,735 associations by consensus.

UNC5B by LYPD3 expression — LARGE_INTESTINE

Explore this box plot interactively →