LYN

Across TCGA patient cohorts, LYN mutation is significantly associated with the RNA expression of many other genes, with 2,688 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LYN-associated genes across cancer lineages are SCARNA11, RPL12P48, and ENSAP3. Each is linked with LYN in more than 2 cancer types. Because this analysis shows association rather than direction, both LYN-to-partner and partner-to-LYN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SCARNA11 grouped by LYN-low versus LYN-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LYN→partner) and Y-score (partner→LYN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	SCARNA11 →	+0.255	+5.033	.009	.009	3	3
LIHC	RPL12P48 →	+0.107	+5.033	<.001	.009	3	2
BRCA	ENSAP3 →	+0.132	+4.153	<.001	.004	3	2
BRCA	ZNF736P9Y →	+0.096	+4.920	<.001	.004	3	2
UCEC	CHAF1A →	+0.716	+3.628	<.001	.001	3	2
SKCM	SYAP1 →	+0.491	+3.198	.004	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,688 associations by consensus.

SCARNA11 by LYN expression — LIHC

Explore this box plot interactively →