LYN

Across TCGA cell cohorts, LYN RNA expression is significantly associated with the go_rna of many other GO terms, with 4,997 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible LYN-associated GO terms across cancer lineages are Fc receptor mediated inhibitory signaling pathway, Eosinophil differentiation, and Positive regulation of dendritic cell apoptotic process. Each is linked with LYN in more than 18 cancer types. Because this analysis shows association rather than direction, both LYN-to-partner and partner-to-LYN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Fc receptor mediated inhibitory signaling pathway grouped by LYN-low versus LYN-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LYN→partner) and Y-score (partner→LYN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Fc receptor mediated inhibitory signaling pathway →	+2.073	+1.927	<.001	<.001	3	19
LIVER	Eosinophil differentiation →	+1.258	+1.601	.002	.004	3	16
BREAST	Positive regulation of dendritic cell apoptotic process →	+1.104	+2.095	<.001	<.001	3	15
SKIN	C-X-C chemokine receptor CXCR4 signaling pathway →	+0.813	+1.239	<.001	<.001	3	12
STOMACH	Negative regulation of B cell receptor signaling pathway →	+0.318	+1.917	<.001	<.001	3	11
BREAST	Regulation of dendritic cell apoptotic process →	+0.902	+2.016	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,997 associations by consensus.

Fc receptor mediated inhibitory signaling pathway by LYN expression — LIVER

Explore this box plot interactively →