LYL1

Across TCGA patient cohorts, LYL1 mutation is significantly associated with the RNA expression of many other genes, with 56 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LYL1-associated genes across cancer lineages are RN7SL248P, RN7SKP60, and RN7SL840P. Each is linked with LYL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LYL1-to-partner and partner-to-LYL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL248P grouped by LYL1-low versus LYL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LYL1→partner) and Y-score (partner→LYL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL248P →	+0.124	+4.400	<.001	.006	3	2
UCEC	RN7SKP60 →	+0.378	+3.520	<.001	.006	3	2
UCEC	RN7SL840P →	+0.480	+3.776	<.001	.001	3	1
UCEC	RPL35P9 →	+0.520	+3.799	<.001	.003	3	1
UCEC	RDH8 →	+0.355	+3.601	.002	.006	3	1
UCEC	RN7SL134P →	+0.253	+4.014	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

RN7SL248P by LYL1 expression — UCEC

Explore this box plot interactively →