LY75

Across TCGA patient cohorts, LY75 mutation is significantly associated with the RNA expression of many other genes, with 5,169 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LY75-associated genes across cancer lineages are NF1P10, ARHGAP11A, and PRC1. Each is linked with LY75 in more than 3 cancer types. Because this analysis shows association rather than direction, both LY75-to-partner and partner-to-LY75 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NF1P10 grouped by LY75-low versus LY75-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LY75→partner) and Y-score (partner→LY75) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	NF1P10 →	+0.413	+3.069	.001	.008	3	4
UCEC	ARHGAP11A →	+0.615	+2.523	<.001	<.001	3	4
UCEC	PRC1 →	+0.689	+1.847	<.001	<.001	3	4
UCEC	HACD2 →	+0.430	+1.716	.001	.001	3	4
UCEC	DBF4P1 →	+0.117	+1.768	<.001	.003	3	4
LUAD	OIP5 →	+0.737	+3.357	.005	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,169 associations by consensus.

NF1P10 by LY75 expression — BLCA

Explore this box plot interactively →