LY75

Across TCGA pan-cancer cohorts, LY75 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of LY75’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where LY75 RNA is repressed in tumor relative to normal tissue. In most cancer types LY75 is over-expressed in tumor, although a few such as KICH and BRCA show the opposite, repressed pattern.

KICH, STAD, and BRCA are the cancer types where LY75 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LY75 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	III,IV	−1.817	<.001	10	view →
STAD	Female	All	+2.091	<.001	8	view →
BRCA	Female	All	−0.861	<.001	6	view →
KIRP	All	All	−0.633	.004	6	view →
ESCA	Female	All	+1.963	<.001	4	view →
BLCA	Male	All	+1.150	.037	3	view →
LUSC	All	II,III,IV	−0.642	.003	3	view →
PRAD	All	All	−0.520	<.001	2	view →
THCA	All	All	−0.386	.003	2	view →
CHOL	All	All	+0.950	.008	1	view →
KIRC	Male	All	+0.365	.018	1	view →
LIHC	Female	All	+0.217	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

LY75–KICH

Open the KICH breakdown →