LY75

Across TCGA patient cohorts, LY75 mutation is significantly associated with the total protein of many other genes, with 69 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LY75-associated genes across cancer lineages are PCNA, Caspase-7-cleavedD198, and Cyclin-E2. Each is linked with LY75 in more than 2 cancer types. Because this analysis shows association rather than direction, both LY75-to-partner and partner-to-LY75 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by LY75-low versus LY75-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LY75→partner) and Y-score (partner→LY75) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PCNA →	+0.234	+2.178	.044	.035	3	3
COAD	Caspase-7-cleavedD198 →	+1.650	+3.330	<.001	.005	3	3
COAD	Cyclin-E2 →	+0.241	+3.025	.027	.018	3	3
UCEC	eIF4E →	+0.168	+1.784	.005	<.001	3	3
UCEC	ATM →	-0.519	-2.379	<.001	<.001	3	3
COAD	EGFR_pY1068 →	-0.431	-3.000	.005	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 69 associations by consensus.

PCNA by LY75 expression — COAD

Explore this box plot interactively →