LY6E

Across TCGA patient cohorts, LY6E protein abundance is significantly associated with the RNA expression of many other genes, with 7,818 significant associations in total. GBM shows the largest number of these associations.

The most reproducible LY6E-associated genes across cancer lineages are IFIT3, IFI44, and HERC6. Each is linked with LY6E in more than 5 cancer types. Because this analysis shows association rather than direction, both LY6E-to-partner and partner-to-LY6E results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LY6E versus IFIT3 in HNSC, with a Pearson correlation of 0.56.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LY6E→partner) and Y-score (partner→LY6E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	IFIT3 →	+1.717	+0.801	<.001	<.001	3	6
HNSC	IFI44 →	+1.325	+0.820	<.001	<.001	3	6
HNSC	HERC6 →	+1.202	+0.842	<.001	<.001	3	6
PDAC	ISG15 →	+1.838	+1.588	<.001	<.001	3	6
HNSC	DDX58 →	+1.052	+0.772	<.001	<.001	3	5
PDAC	OAS3 →	+1.429	+1.462	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,818 associations by consensus.

LY6E vs IFIT3 — HNSC

Explore this scatter interactively →