LY6E

Across TCGA cell cohorts, LY6E RNA expression is significantly associated with the go_rna of many other GO terms, with 4,765 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible LY6E-associated GO terms across cancer lineages are Regulation of pattern recognition receptor signaling pathway, Regulation of viral genome replication, and Regulation of viral process. Each is linked with LY6E in more than 10 cancer types. Because this analysis shows association rather than direction, both LY6E-to-partner and partner-to-LY6E results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of pattern recognition receptor signaling pathway grouped by LY6E-low versus LY6E-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LY6E→partner) and Y-score (partner→LY6E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Regulation of pattern recognition receptor signaling pathway →	+0.065	+2.064	<.001	.002	3	11
PANCREAS	Regulation of viral genome replication →	+0.108	+1.383	<.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	Regulation of viral process →	+0.120	+1.502	<.001	<.001	3	10
BONE	Regulation of cytoplasmic pattern recognition receptor signaling pathway →	+0.068	+1.463	.001	<.001	3	10
BLOOD_Lymphoma	Positive regulation of inflammatory response →	+0.077	+2.935	<.001	<.001	3	10
KIDNEY	Viral process →	+0.067	+1.858	.001	.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,765 associations by consensus.

Regulation of pattern recognition receptor signaling pathway by LY6E expression — KIDNEY

Explore this box plot interactively →