LY6E

Across TCGA cell cohorts, LY6E mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LY6E-associated genes across cancer lineages are LRIT1, BPIFB6, and OR13H1. Each is linked with LY6E in more than 1 cancer types. Because this analysis shows association rather than direction, both LY6E-to-partner and partner-to-LY6E results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LRIT1 grouped by LY6E-low versus LY6E-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LY6E→partner) and Y-score (partner→LY6E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LRIT1 →	+0.020	+3.994	.003	.002	3	1
LARGE_INTESTINE	BPIFB6 →	+0.016	+4.022	<.001	.006	3	1
LARGE_INTESTINE	OR13H1 →	+0.100	+3.766	<.001	.004	3	1
LARGE_INTESTINE	COL25A1 →	+0.042	+4.070	.007	.003	3	1
LARGE_INTESTINE	CELA2B →	+0.037	+3.688	.008	.002	3	1
LARGE_INTESTINE	IQCF3 →	+0.044	+3.345	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

LRIT1 by LY6E expression — LARGE_INTESTINE

Explore this box plot interactively →