LY6D

Across TCGA cell cohorts, LY6D RNA expression is significantly associated with the go_rna of many other GO terms, with 2,050 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible LY6D-associated GO terms across cancer lineages are Positive regulation of iron ion transport, Positive regulation of iron ion transmembrane transport, and NMDA selective glutamate receptor signaling pathway. Each is linked with LY6D in more than 10 cancer types. Because this analysis shows association rather than direction, both LY6D-to-partner and partner-to-LY6D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of iron ion transport grouped by LY6D-low versus LY6D-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LY6D→partner) and Y-score (partner→LY6D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Positive regulation of iron ion transport →	+1.453	+3.499	<.001	<.001	3	11
URINARY_TRACT	Positive regulation of iron ion transmembrane transport →	+1.453	+3.499	<.001	<.001	3	11
BREAST	NMDA selective glutamate receptor signaling pathway →	+0.202	+2.435	<.001	<.001	3	8
URINARY_TRACT	Regulation of hippocampal neuron apoptotic process →	+1.433	+3.540	<.001	<.001	3	8
URINARY_TRACT	Protein localization to juxtaparanode region of axon →	-1.504	-3.448	<.001	<.001	3	7
URINARY_TRACT	Negative regulation of hippocampal neuron apoptotic process →	+1.355	+3.540	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,050 associations by consensus.

Positive regulation of iron ion transport by LY6D expression — URINARY_TRACT

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