LXN

Across TCGA patient cohorts, LXN mutation is significantly associated with the immune_cell of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LXN-associated genes across cancer lineages are Erythrocytes, lymphatic Endothelial cells, and mv Endothelial cells. Each is linked with LXN in more than 1 cancer types. Because this analysis shows association rather than direction, both LXN-to-partner and partner-to-LXN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Erythrocytes grouped by LXN-low versus LXN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LXN→partner) and Y-score (partner→LXN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Erythrocytes →	+0.048	+3.000	<.001	.037	3	1
UCEC	lymphatic Endothelial cells →	-0.029	-2.946	.035	.037	1	1
UCEC	mv Endothelial cells →	-0.035	-2.989	.011	.037	1	1
UCEC	Basophils →	+0.268	+3.000	.006	.037	1	1
UCEC	Plasma cells →	-0.027	-2.957	.032	.037	1	1
UCEC	pro B-cells →	+0.181	+3.000	.003	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Erythrocytes by LXN expression — UCEC

Explore this box plot interactively →