LXN

Across TCGA pan-cancer cohorts, LXN RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated LXN data layer compared with 3 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher LXN RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated LXN expression acts as an unfavorable survival marker, although some lineages such as KIRC and SARC show a favorable association.

KIRP, KIRC, and LGG are the cancer types where LXN RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Quartile	II,III,IV	0.219	0.672	<.001	89	view →
KIRC	DFS	Quartile	All	0.853	0.650	.002	56	view →
LGG	DFS	Median	All	0.670	0.800	<.001	53	view →
SARC	OS	Quartile	All	0.895	0.626	.002	28	view →
UVM	DFS	Tertile	II,III,IV	0.343	0.731	.014	23	view →
CESC	DFS	Tertile	All	0.412	0.662	.008	16	view →
UCEC	OS	Median	All	0.536	0.796	.016	14	view →
LIHC	DFS	Tertile	III,IV	0.525	0.187	.002	14	view →
CHOL	DFS	Tertile	All	0.594	0.130	.026	12	view →
OV	DFS	Quartile	IV	0.326	0.674	.003	12	view →
ACC	DFS	Median	III,IV	0.816	0.297	.006	11	view →
PCPG	DFS	Tertile	All	0.980	0.790	.003	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

LXN–KIRP (DFS)

Open the KIRP breakdown →