LVRN

Across TCGA cell cohorts, LVRN protein abundance is significantly associated with the go_rna of many other GO terms, with 398 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible LVRN-associated GO terms across cancer lineages are SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition, Neuroendocrine cell differentiation, and Vacuolar localization. Each is linked with LVRN in more than 2 cancer types. Because this analysis shows association rather than direction, both LVRN-to-partner and partner-to-LVRN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition grouped by LVRN-low versus LVRN-high in LARGE_INTESTINE.

protein abundance associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LVRN→partner) and Y-score (partner→LVRN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition →	-0.094	-0.987	.004	.006	3	2
BLOOD_Lymphoma	Neuroendocrine cell differentiation →	-0.218	-0.702	.004	.004	3	2
LUNG_SCLC	Vacuolar localization →	+0.077	+0.810	<.001	<.001	3	2
LUNG_SCLC	Cellular response to heat →	+0.093	+0.634	.004	.001	3	2
LUNG_SCLC	tRNA-type intron splice site recognition and cleavage →	-0.097	-0.910	.007	.004	3	2
LUNG_SCLC	Negative regulation of neurotransmitter transport →	+0.157	+0.926	.002	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 398 associations by consensus.

SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition by LVRN expression — LARGE_INTESTINE

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