leucine rich adaptor protein 1Genealiases: C1orf190 · LRAP35a · LRP35A
Q-omics provides the consensus-scored LURAP1 profile across patient tissues and cancer cell-line models. LURAP1 expression is associated with patient survival in 24 of 34 cancer types, with the highest sampling consensus in UVM. Among the 18 cancer types available for tumor–normal comparison, LURAP1 is differentially expressed in 16, with the highest sampling consensus in KIRC. Additionally, LURAP1 RNA expression shows 19,288 significant gene co-expression associations, with the highest sampling consensus in THYM. Together, these results highlight UVM, KIRC, and THYM as cancer lineages where LURAP1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for LURAP1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes LURAP1 survival associations across molecular data types. LURAP1 RNA expression shows survival associations in the most cancer types (24), followed by mutation status (1) and mass-spec protein abundance (1). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible LURAP1 RNA expression–survival associations across cancer types. High LURAP1 expression shows unfavorable associations in LGG, UCS, MESO and COAD, but favorable associations in UVM and LUAD. The UVM Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify UVM as the clearest survival context for LURAP1 RNA expression.
This table summarizes LURAP1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 16, while mass-spec protein shows differences in 2. The strongest signals are observed in KIRC for RNA and LSCC for protein.
This table ranks reproducible tumor–normal expression differences for LURAP1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. LURAP1 shows lower tumor expression in KIRC, BLCA, THCA, KICH, UCEC and BRCA. The KIRC box plot shows higher LURAP1 RNA expression in normal versus tumor tissue (log2 FC = −1.766, t-test p < 0.001).
This table shows molecular features associated with LURAP1 in patient tissues and cancer cell lines. In patient samples, LURAP1 shows the broadest associations at the RNA and protein expression levels, with THYM recurring as the lineage with the largest associated feature set. In cancer cell lines, LURAP1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LUNG_SCLC, while CRISPR and shRNA rows add functional-dependency signals in PANCREAS and BLOOD_Leukemia.
