LUARIS

Across TCGA pan-cancer cohorts, LUARIS RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated LUARIS data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher LUARIS RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated LUARIS expression acts as an unfavorable survival marker, although some lineages such as SKCM and ESCA show a favorable association.

KIRC, KICH, and MESO are the cancer types where LUARIS RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.517	0.712	<.001	90	view →
KICH	DFS	Tertile	All	0.370	0.939	<.001	76	view →
MESO	OS	Quartile	All	0.398	0.723	<.001	66	view →
THCA	OS	Quartile	III,IV	0.916	1.000	<.001	51	view →
STAD	DFS	Tertile	All	0.277	0.536	.002	50	view →
UVM	DFS	Tertile	All	0.263	0.643	.001	45	view →
ACC	OS	Quartile	II,III,IV	0.693	0.927	.003	42	view →
BLCA	DFS	Median	All	0.454	0.559	.006	37	view →
HNSC	OS	Tertile	III,IV	0.545	0.819	.003	29	view →
PAAD	OS	Median	II,III,IV	0.443	0.660	.009	22	view →
DLBC	OS	Median	III,IV	0.272	1.000	.017	16	view →
LUSC	OS	Tertile	III,IV	0.583	0.831	.008	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

LUARIS–KIRC (DFS)

Open the KIRC breakdown →