LTK

Across TCGA patient cohorts, LTK mutation is significantly associated with the RNA expression of many other genes, with 3,247 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LTK-associated genes across cancer lineages are PSMA4, TACC3, and RNU6-434P. Each is linked with LTK in more than 2 cancer types. Because this analysis shows association rather than direction, both LTK-to-partner and partner-to-LTK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PSMA4 grouped by LTK-low versus LTK-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LTK→partner) and Y-score (partner→LTK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PSMA4 →	+0.384	+1.769	.004	.004	3	3
UCEC	TACC3 →	+0.646	+2.070	<.001	.001	3	3
LIHC	RNU6-434P →	+0.236	+5.091	<.001	.003	3	2
LIHC	SNORA3C →	+0.207	+4.720	<.001	.005	3	2
SKCM	RNU7-79P →	+0.226	+3.098	<.001	.008	3	2
SKCM	RPPH1-3P →	+0.082	+4.049	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,247 associations by consensus.

PSMA4 by LTK expression — UCEC

Explore this box plot interactively →