LTK

Across TCGA cell cohorts, LTK RNA expression is significantly associated with the go_rna of many other GO terms, with 2,299 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible LTK-associated GO terms across cancer lineages are Positive regulation of striated muscle cell apoptotic process, Positive regulation of cardiac muscle cell apoptotic process, and Cytoplasmic translation. Each is linked with LTK in more than 6 cancer types. Because this analysis shows association rather than direction, both LTK-to-partner and partner-to-LTK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of striated muscle cell apoptotic process grouped by LTK-low versus LTK-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LTK→partner) and Y-score (partner→LTK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of striated muscle cell apoptotic process →	-0.208	-1.368	<.001	.003	2	7
BONE	Positive regulation of cardiac muscle cell apoptotic process →	-0.208	-1.368	<.001	.003	2	7
SOFT_TISSUE	Cytoplasmic translation →	+0.053	+1.247	.002	.007	3	5
SOFT_TISSUE	RNA splicing, via transesterification reactions →	+0.049	+1.351	<.001	<.001	3	5
SOFT_TISSUE	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile →	+0.049	+1.351	<.001	<.001	3	5
SOFT_TISSUE	mRNA splicing, via spliceosome →	+0.049	+1.351	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,299 associations by consensus.

Positive regulation of striated muscle cell apoptotic process by LTK expression — BONE

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