LTF

Across TCGA pan-cancer cohorts, LTF mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated LTF data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher LTF mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated LTF expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

HNSC, PDAC, and LUAD are the cancer types where LTF mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.378	1.000	.001	35	view →
PDAC	OS	Tertile	All	0.144	0.868	.024	25	view →
LUAD	DFS	Tertile	All	0.346	0.913	<.001	11	view →
LSCC	DFS	Tertile	All	0.852	0.416	.035	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

LTF–HNSC (OS)

Open the HNSC breakdown →