LTBP1

Across TCGA patient cohorts, LTBP1 mutation is significantly associated with the total protein of many other genes, with 77 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LTBP1-associated genes across cancer lineages are ASNS, PCNA, and eIF4E. Each is linked with LTBP1 in more than 4 cancer types. Because this analysis shows association rather than direction, both LTBP1-to-partner and partner-to-LTBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by LTBP1-low versus LTBP1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LTBP1→partner) and Y-score (partner→LTBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ASNS →	+0.374	+2.459	.019	.017	3	5
STAD	PCNA →	+0.303	+3.321	.012	.008	3	4
UCEC	eIF4E →	+0.143	+2.392	.015	<.001	3	4
LUAD	Chk2 →	+0.252	+1.906	.003	.014	3	3
LUAD	FoxM1 →	+0.182	+1.584	.040	.018	3	3
COAD	Rad50 →	-0.283	-1.691	.002	.043	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 77 associations by consensus.

ASNS by LTBP1 expression — LUAD

Explore this box plot interactively →