LTBP1

Across TCGA pan-cancer cohorts, LTBP1 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated LTBP1 data layer compared with 12 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher LTBP1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated LTBP1 expression acts as an unfavorable survival marker, although some lineages such as DLBC and ESCA show a favorable association.

ACC, KIRP, and BLCA are the cancer types where LTBP1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.136	0.696	<.001	155	view →
KIRP	DFS	Median	All	0.783	0.927	<.001	144	view →
BLCA	OS	Quartile	All	0.262	0.511	<.001	102	view →
MESO	OS	Median	All	0.247	0.519	<.001	96	view →
LGG	OS	Median	All	0.730	0.888	<.001	49	view →
DLBC	DFS	Median	IV	1.000	0.412	.006	32	view →
BRCA	OS	Median	II,III,IV	0.506	0.622	.009	28	view →
ESCA	DFS	Tertile	III,IV	0.609	0.325	.003	27	view →
UVM	DFS	Median	All	0.621	0.331	.002	21	view →
KICH	OS	Tertile	All	0.693	1.000	.023	17	view →
COAD	DFS	Median	All	0.714	0.840	.005	17	view →
HNSC	DFS	Quartile	III,IV	0.424	0.741	.004	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

LTBP1–ACC (DFS)

Open the ACC breakdown →