LTBP1

Across TCGA cell cohorts, LTBP1 mutation is significantly associated with the RNA expression of many other genes, with 980 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LTBP1-associated genes across cancer lineages are VWA3B, OTOR, and SERPINA7. Each is linked with LTBP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both LTBP1-to-partner and partner-to-LTBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VWA3B grouped by LTBP1-low versus LTBP1-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LTBP1→partner) and Y-score (partner→LTBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	VWA3B →	+0.034	+4.285	<.001	.003	3	3
URINARY_TRACT	OTOR →	+0.030	+5.087	<.001	.004	3	3
LUNG_NSCLC_LUAD	SERPINA7 →	+0.004	+2.906	<.001	<.001	3	3
CNS	OR52L1 →	+0.046	+4.321	<.001	.009	3	3
LARGE_INTESTINE	SEC24B →	+0.648	+2.628	<.001	.002	3	3
BREAST	OCM2 →	+0.054	+4.196	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 980 associations by consensus.

VWA3B by LTBP1 expression — BLOOD_Myeloma

Explore this box plot interactively →