LTA4H

Across TCGA patient cohorts, LTA4H mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LTA4H-associated genes across cancer lineages are EGFR_pY1068, JNK_pT183_Y185, and Ku80. Each is linked with LTA4H in more than 1 cancer types. Because this analysis shows association rather than direction, both LTA4H-to-partner and partner-to-LTA4H results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by LTA4H-low versus LTA4H-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LTA4H→partner) and Y-score (partner→LTA4H) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.292	-3.584	.007	.002	3	1
UCEC	JNK_pT183_Y185 →	-0.250	-3.700	<.001	.001	3	1
UCEC	Ku80 →	+0.223	+1.598	.030	.044	3	1
UCEC	MEK1 →	+0.470	+2.807	.003	.003	3	1
UCEC	Notch1 →	+0.198	+2.807	.001	.003	3	1
UCEC	PDCD4 →	-0.526	-2.999	.010	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

EGFR_pY1068 by LTA4H expression — UCEC

Explore this box plot interactively →