LTA4H

Across TCGA cell cohorts, LTA4H RNA expression is significantly associated with the go_rna of many other GO terms, with 3,481 significant associations in total. BONE shows the largest number of these associations.

The most reproducible LTA4H-associated GO terms across cancer lineages are Negative regulation of stress-activated MAPK cascade, Lung cell differentiation, and Lung epithelial cell differentiation. Each is linked with LTA4H in more than 8 cancer types. Because this analysis shows association rather than direction, both LTA4H-to-partner and partner-to-LTA4H results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of stress-activated MAPK cascade grouped by LTA4H-low versus LTA4H-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LTA4H→partner) and Y-score (partner→LTA4H) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Negative regulation of stress-activated MAPK cascade →	+0.110	+0.494	.007	.005	3	9
SOFT_TISSUE	Lung cell differentiation →	+0.249	+0.650	.001	.007	3	9
SOFT_TISSUE	Lung epithelial cell differentiation →	+0.249	+0.650	.001	.007	3	9
LUNG_SCLC	Transcription initiation at mitochondrial promoter →	+0.135	+0.628	<.001	<.001	3	8
LIVER	Translation reinitiation →	+0.139	+0.743	.001	<.001	3	8
OVARY	Regulation of neurotrophin TRK receptor signaling pathway →	+0.206	+0.772	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,481 associations by consensus.

Negative regulation of stress-activated MAPK cascade by LTA4H expression — LUNG_SCLC

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