Across TCGA cell cohorts, LTA mutation is significantly associated with the RNA expression of many other genes, with 43 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LTA-associated genes across cancer lineages are OR10W1, WNT2, and DCN. Each is linked with LTA in more than 1 cancer types. Because this analysis shows association rather than direction, both LTA-to-partner and partner-to-LTA results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LTA→partner) and Y-score (partner→LTA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR10W1 →	+0.019	+5.562	<.001	<.001	3	1
SKIN	WNT2 →	+0.500	+3.497	.009	.004	3	1
SKIN	DCN →	+1.355	+3.067	.002	.009	3	1
SKIN	ENAM →	+0.079	+2.560	<.001	.009	3	1
SKIN	KANK4 →	+0.221	+2.648	.001	.008	3	1
SKIN	MSMP →	+0.730	+2.839	.004	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

Exploration

LTA survival (RNA) · tumor vs normal (RNA) · all LTA data types