LSR

Across TCGA patient cohorts, LSR mutation is significantly associated with the RNA expression of many other genes, with 1,741 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LSR-associated genes across cancer lineages are MIR4662B, RNU6-1089P, and RNU6-176P. Each is linked with LSR in more than 2 cancer types. Because this analysis shows association rather than direction, both LSR-to-partner and partner-to-LSR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4662B grouped by LSR-low versus LSR-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LSR→partner) and Y-score (partner→LSR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	MIR4662B →	+0.719	+5.093	<.001	.008	3	3
READ	RNU6-1089P →	+0.354	+4.421	<.001	.009	3	2
READ	RNU6-176P →	+0.349	+5.257	<.001	.002	3	2
READ	MIR4298 →	+0.463	+4.653	<.001	.007	3	2
UCEC	MON1A →	+0.485	+2.906	<.001	.002	3	2
UCEC	PXMP2 →	+0.755	+3.601	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,741 associations by consensus.

MIR4662B by LSR expression — LUSC

Explore this box plot interactively →