LSR

Across TCGA pan-cancer cohorts, LSR RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of LSR’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where LSR RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LSR is over-expressed in tumor, although a few such as LIHC show the opposite, repressed pattern.

HNSC, THCA, and LUAD are the cancer types where LSR tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LSR RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+1.636	<.001	11	view →
THCA	Male	III,IV	+0.929	<.001	10	view →
LUAD	Male	II,III,IV	+1.302	<.001	9	view →
STAD	Male	All	+2.281	<.001	8	view →
BLCA	All	All	+1.978	.002	8	view →
LUSC	Female	All	+1.509	<.001	8	view →
COAD	All	II,III,IV	+0.396	.006	8	view →
BRCA	All	All	+1.410	<.001	6	view →
KIRP	All	IV	+1.719	.005	5	view →
UCEC	All	All	+1.706	<.001	4	view →
ESCA	All	All	+1.570	.002	4	view →
PAAD	All	All	+1.997	.031	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

LSR–HNSC

Open the HNSC breakdown →