LSR

Across TCGA patient cohorts, LSR mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LSR-associated genes across cancer lineages are eEF2, FoxM1, and INPP4B. Each is linked with LSR in more than 1 cancer types. Because this analysis shows association rather than direction, both LSR-to-partner and partner-to-LSR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by LSR-low versus LSR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LSR→partner) and Y-score (partner→LSR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.552	+2.584	<.001	.011	3	2
UCEC	FoxM1 →	+0.281	+2.584	.020	.011	3	2
UCEC	INPP4B →	-0.404	-3.321	.007	.009	3	2
UCEC	MEK1 →	+0.366	+3.169	.032	.019	3	2
UCEC	RAD51 →	+0.154	+3.000	.018	.036	3	2
UCEC	Shc_pY317 →	-0.180	-3.000	.010	.036	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

eEF2 by LSR expression — UCEC

Explore this box plot interactively →