LSR

Across TCGA cell cohorts, LSR mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LSR-associated genes across cancer lineages are HSFY1, OR10K2, and PABPC1L2A. Each is linked with LSR in more than 1 cancer types. Because this analysis shows association rather than direction, both LSR-to-partner and partner-to-LSR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HSFY1 grouped by LSR-low versus LSR-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LSR→partner) and Y-score (partner→LSR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	HSFY1 →	+0.117	+3.817	<.001	.004	3	1
BREAST	OR10K2 →	+0.063	+5.781	<.001	.001	3	1
BREAST	PABPC1L2A →	+0.083	+5.169	<.001	.005	3	1
BREAST	OR10T2 →	+0.183	+5.781	<.001	.001	3	1
LUNG_NSCLC_LUAD	C7orf77 →	+0.072	+5.662	<.001	.002	3	1
LARGE_INTESTINE	SULT6B1 →	+0.024	+3.240	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

HSFY1 by LSR expression — LUNG_SCLC

Explore this box plot interactively →