LSMEM1

Across TCGA patient cohorts, LSMEM1 mutation is significantly associated with the RNA expression of many other genes, with 374 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LSMEM1-associated genes across cancer lineages are LINC02662, MIR6082, and YWHAQP1. Each is linked with LSMEM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LSMEM1-to-partner and partner-to-LSMEM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC02662 grouped by LSMEM1-low versus LSMEM1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LSMEM1→partner) and Y-score (partner→LSMEM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	LINC02662 →	+0.154	+4.771	<.001	<.001	3	2
BRCA	MIR6082 →	+1.153	+8.471	<.001	.005	3	1
SKCM	YWHAQP1 →	+0.139	+4.180	<.001	.001	3	1
SKCM	RN7SL220P →	+0.165	+3.243	<.001	.009	3	1
BRCA	DEFB114 →	+0.443	+7.731	<.001	.009	3	1
BRCA	RNU6-500P →	+1.158	+7.731	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 374 associations by consensus.

LINC02662 by LSMEM1 expression — SKCM

Explore this box plot interactively →