LSMEM1

Across TCGA pan-cancer cohorts, LSMEM1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of LSMEM1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where LSMEM1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LSMEM1 is over-expressed in tumor, although a few such as THCA and BRCA show the opposite, repressed pattern.

KIRC, LIHC, and THCA are the cancer types where LSMEM1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LSMEM1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	IV	+0.592	<.001	12	view →
LIHC	Female	All	+0.400	<.001	7	view →
THCA	All	All	−0.266	.001	6	view →
BRCA	Female	All	−0.264	<.001	6	view →
HNSC	Male	All	−0.730	.007	4	view →
READ	All	II,III,IV	+0.620	.014	4	view →
KICH	All	II,III,IV	+0.479	.006	4	view →
UCEC	All	II,III,IV	+0.413	.027	4	view →
LUSC	Female	All	−0.447	.003	3	view →
CHOL	Female	All	+1.086	.002	2	view →
COAD	Male	II,III,IV	+0.421	.015	2	view →
KIRP	Female	All	+0.370	.041	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

LSMEM1–KIRC

Open the KIRC breakdown →