LSMEM1

Across TCGA patient cohorts, LSMEM1 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LSMEM1-associated genes across cancer lineages are GAPDH, JNK2, and Ku80. Each is linked with LSMEM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LSMEM1-to-partner and partner-to-LSMEM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by LSMEM1-low versus LSMEM1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LSMEM1→partner) and Y-score (partner→LSMEM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.650	+3.000	.036	.037	3	1
UCEC	JNK2 →	+0.377	+2.834	.001	.034	3	1
UCEC	Ku80 →	+0.295	+3.013	.031	.019	3	1
UCEC	mTOR_pS2448 →	-0.186	-3.000	.030	.037	3	1
UCEC	NF2 →	+0.376	+3.000	.002	.037	3	1
UCEC	VHL →	-1.565	-3.000	<.001	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

GAPDH by LSMEM1 expression — UCEC

Explore this box plot interactively →