LSM8

Across TCGA pan-cancer cohorts, LSM8 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated LSM8 data layer compared with 25 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher LSM8 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated LSM8 expression acts as an unfavorable survival marker, although some lineages such as LSCC and GBM show a favorable association.

LSCC, GBM, and HNSC are the cancer types where LSM8 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	All	1.000	0.918	.009	21	view →
GBM	OS	Median	All	0.475	0.281	.007	7	view →
HNSC	OS	Median	All	0.959	1.000	.023	5	view →
LUAD	DFS	Tertile	II,III,IV	0.742	0.267	.035	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

LSM8–LSCC (DFS)

Open the LSCC breakdown →