LSM6

Across TCGA patient cohorts, LSM6 mutation is significantly associated with the RNA expression of many other genes, with 155 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LSM6-associated genes across cancer lineages are MIR520A, YME1L1P1, and IL21. Each is linked with LSM6 in more than 1 cancer types. Because this analysis shows association rather than direction, both LSM6-to-partner and partner-to-LSM6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR520A grouped by LSM6-low versus LSM6-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LSM6→partner) and Y-score (partner→LSM6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MIR520A →	+0.771	+7.741	<.001	.009	3	1
COAD	YME1L1P1 →	+0.313	+7.741	<.001	.009	3	1
UCEC	IL21 →	+0.187	+4.611	.002	<.001	3	1
UCEC	AQP7P2 →	+0.271	+4.595	<.001	<.001	3	1
UCEC	MIR367 →	+0.781	+3.520	<.001	.002	3	1
UCEC	RNU4-82P →	+0.741	+3.863	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 155 associations by consensus.

MIR520A by LSM6 expression — COAD

Explore this box plot interactively →