LSM6

Across TCGA pan-cancer cohorts, LSM6 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated LSM6 data layer compared with 2 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher LSM6 RNA is associated with better overall survival. In most high-consensus cancer types, elevated LSM6 expression acts as an unfavorable survival marker, although some lineages such as SKCM and KIRC show a favorable association.

SKCM, LIHC, and KIRP are the cancer types where LSM6 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Quartile	All	0.390	0.219	<.001	77	view →
LIHC	DFS	Quartile	All	0.411	0.617	<.001	55	view →
KIRP	DFS	Median	II,III,IV	0.286	0.686	.001	47	view →
KIRC	DFS	Tertile	All	0.885	0.689	<.001	40	view →
HNSC	OS	Median	All	0.289	0.497	.003	29	view →
KICH	DFS	Quartile	III,IV	0.169	0.913	.003	27	view →
ACC	DFS	Quartile	II,III,IV	0.178	0.777	<.001	26	view →
READ	DFS	Median	II,III,IV	0.774	0.257	.010	22	view →
BRCA	OS	Median	III,IV	0.689	0.374	<.001	18	view →
ESCA	DFS	Tertile	All	0.384	0.584	.015	18	view →
MESO	DFS	Median	II,III,IV	0.228	0.672	<.001	15	view →
LGG	DFS	Tertile	All	0.758	0.905	.001	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

LSM6–SKCM (OS)

Open the SKCM breakdown →