LSM6

Across TCGA cell cohorts, LSM6 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,787 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LSM6-associated GO terms across cancer lineages are U1 snRNA 3'-end processing, U5 snRNA 3'-end processing, and Regulation of DNA replication. Each is linked with LSM6 in more than 17 cancer types. Because this analysis shows association rather than direction, both LSM6-to-partner and partner-to-LSM6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, U1 snRNA 3'-end processing grouped by LSM6-low versus LSM6-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LSM6→partner) and Y-score (partner→LSM6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	U1 snRNA 3'-end processing →	+0.139	+1.016	<.001	<.001	3	18
LUNG_NSCLC_LUSC	U5 snRNA 3'-end processing →	+0.139	+1.016	<.001	<.001	3	18
BONE	Regulation of DNA replication →	+0.077	+0.603	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Mitotic DNA replication checkpoint signaling →	+0.124	+0.682	<.001	<.001	3	16
BREAST	Nuclear polyadenylation-dependent rRNA catabolic process →	+0.104	+0.799	<.001	.002	3	15
BREAST	TRAMP-dependent tRNA surveillance pathway →	+0.104	+0.799	<.001	.002	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,787 associations by consensus.

U1 snRNA 3'-end processing by LSM6 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →