LSM4

Across TCGA patient cohorts, LSM4 mutation is significantly associated with the RNA expression of many other genes, with 99 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LSM4-associated genes across cancer lineages are RNA5SP68, MIR6509, and MIR6775. Each is linked with LSM4 in more than 1 cancer types. Because this analysis shows association rather than direction, both LSM4-to-partner and partner-to-LSM4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP68 grouped by LSM4-low versus LSM4-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LSM4→partner) and Y-score (partner→LSM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNA5SP68 →	+0.357	+5.324	<.001	.001	3	2
UCEC	MIR6509 →	+0.433	+2.499	.006	.002	3	1
UCEC	MIR6775 →	+0.477	+2.656	.001	.001	3	1
UCEC	ZBTB8OSP1 →	+0.259	+2.791	.004	<.001	3	1
LUSC	RNU6-796P →	+0.374	+4.548	<.001	.009	3	1
LUSC	ZDHHC20P2 →	+0.083	+5.081	.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 99 associations by consensus.

RNA5SP68 by LSM4 expression — LUSC

Explore this box plot interactively →