LSM4

Across TCGA pan-cancer cohorts, LSM4 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of LSM4’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where LSM4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LSM4 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

HNSC, BLCA, and COAD are the cancer types where LSM4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LSM4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+1.205	<.001	12	view →
BLCA	Male	All	+1.181	<.001	11	view →
COAD	Male	IV	+1.041	<.001	11	view →
LIHC	Female	II,III,IV	+1.635	<.001	9	view →
STAD	Female	All	+1.357	<.001	9	view →
LUAD	All	All	+0.469	<.001	8	view →
LUSC	Female	All	+1.335	<.001	7	view →
UCEC	All	III,IV	+1.282	<.001	6	view →
BRCA	All	III,IV	+1.089	<.001	6	view →
KIRC	Male	All	−0.311	<.001	6	view →
KIRP	Female	II,III,IV	+0.570	<.001	4	view →
THCA	All	All	+0.179	.014	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

LSM4–HNSC

Open the HNSC breakdown →