LSM4

Across TCGA cell cohorts, LSM4 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,498 significant associations in total. BONE shows the largest number of these associations.

The most reproducible LSM4-associated GO terms across cancer lineages are Mitotic chromosome condensation, Double-strand break repair via break-induced replication, and Regulation of DNA-templated DNA replication. Each is linked with LSM4 in more than 14 cancer types. Because this analysis shows association rather than direction, both LSM4-to-partner and partner-to-LSM4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitotic chromosome condensation grouped by LSM4-low versus LSM4-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LSM4→partner) and Y-score (partner→LSM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Mitotic chromosome condensation →	+0.214	+0.950	.002	.001	3	15
BONE	Double-strand break repair via break-induced replication →	+0.259	+1.067	.005	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Regulation of DNA-templated DNA replication →	+0.124	+1.149	<.001	<.001	3	14
BONE	Mitotic DNA replication →	+0.233	+0.890	.002	.002	2	14
BLOOD_Lymphoma	Cellular response to cisplatin →	+0.161	+0.984	<.001	<.001	3	13
BLOOD_Myeloma	DNA replication checkpoint signaling →	+0.194	+1.046	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,498 associations by consensus.

Mitotic chromosome condensation by LSM4 expression — BONE

Explore this box plot interactively →