Across TCGA patient cohorts, LSM2 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LSM2-associated genes across cancer lineages are RNA5SP389, MIR199B, and ELOBP3. Each is linked with LSM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both LSM2-to-partner and partner-to-LSM2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LSM2→partner) and Y-score (partner→LSM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNA5SP389 →	+0.400	+7.040	<.001	<.001	3	1
UCEC	MIR199B →	+0.585	+5.852	<.001	.003	3	1
UCEC	ELOBP3 →	+0.473	+5.420	<.001	.005	3	1
UCEC	RN7SL215P →	+0.352	+5.694	<.001	.003	3	1
UCEC	RNU6ATAC17P →	+0.776	+5.186	<.001	.007	3	1
UCEC	RNA5SP408 →	+0.585	+5.186	.008	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Exploration

LSM2 survival (RNA) · tumor vs normal (RNA) · all LSM2 data types