LSM12P1

Across TCGA pan-cancer cohorts, LSM12P1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of LSM12P1’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where LSM12P1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LSM12P1 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

BLCA, HNSC, and LUAD are the cancer types where LSM12P1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LSM12P1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	III,IV	+0.835	<.001	11	view →
HNSC	Male	III,IV	+1.003	<.001	9	view →
LUAD	Male	II,III,IV	+0.821	<.001	9	view →
LUSC	Female	All	+1.074	<.001	7	view →
KICH	Female	All	−0.924	<.001	7	view →
KIRP	All	II,III,IV	+0.430	.004	7	view →
BRCA	All	All	+0.552	<.001	6	view →
CHOL	All	All	+1.053	<.001	5	view →
LIHC	Male	All	+0.696	<.001	4	view →
THCA	All	All	−0.273	.020	2	view →
ESCA	All	All	+0.903	.026	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

LSM12P1–BLCA

Open the BLCA breakdown →