LSM11

Across TCGA patient cohorts, LSM11 mutation is significantly associated with the RNA expression of many other genes, with 1,795 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LSM11-associated genes across cancer lineages are RNU2-8P, RNU1-17P, and RNU4-58P. Each is linked with LSM11 in more than 1 cancer types. Because this analysis shows association rather than direction, both LSM11-to-partner and partner-to-LSM11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU2-8P grouped by LSM11-low versus LSM11-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LSM11→partner) and Y-score (partner→LSM11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU2-8P →	+0.437	+7.741	<.001	.009	3	2
UCEC	RNU1-17P →	+0.263	+2.713	<.001	<.001	3	2
UCEC	RNU4-58P →	+0.166	+2.548	.005	.002	3	2
SKCM	RN7SL282P →	+0.171	+4.594	<.001	.008	3	2
SKCM	RNU7-60P →	+0.393	+5.080	<.001	.004	3	2
BRCA	MIR6511A1 →	+0.413	+8.471	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,795 associations by consensus.

RNU2-8P by LSM11 expression — COAD

Explore this box plot interactively →