LSAMP-AS1

Across TCGA pan-cancer cohorts, LSAMP-AS1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of LSAMP-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where LSAMP-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LSAMP-AS1 is over-expressed in tumor.

HNSC, LUSC, and THCA are the cancer types where LSAMP-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LSAMP-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+0.686	<.001	8	view →
LUSC	All	All	+1.131	<.001	6	view →
THCA	All	All	+0.093	.002	4	view →
LIHC	Female	All	+0.058	.008	4	view →
LUAD	All	All	+0.461	.001	3	view →
PAAD	All	All	+1.895	.031	2	view →
BLCA	All	All	+0.422	.044	2	view →
BRCA	Female	All	+0.136	.012	2	view →
STAD	All	All	+0.439	.025	1	view →
COAD	All	II,III,IV	+0.218	.047	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

LSAMP-AS1–HNSC

Open the HNSC breakdown →