LRRTM4

Across TCGA patient cohorts, LRRTM4 mutation is significantly associated with the total protein of many other genes, with 63 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRTM4-associated genes across cancer lineages are 4E-BP1, Caspase-7-cleavedD198, and TFRC. Each is linked with LRRTM4 in more than 3 cancer types. Because this analysis shows association rather than direction, both LRRTM4-to-partner and partner-to-LRRTM4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by LRRTM4-low versus LRRTM4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRTM4→partner) and Y-score (partner→LRRTM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.326	+3.087	<.001	<.001	3	4
UCEC	Caspase-7-cleavedD198 →	+0.411	+1.827	.014	.002	3	4
UCEC	TFRC →	+0.625	+2.000	<.001	<.001	3	3
UCEC	TIGAR →	+0.132	+1.810	.002	<.001	3	3
UCEC	Cyclin-B1 →	+0.617	+1.784	<.001	<.001	3	3
UCEC	Heregulin →	-0.131	-2.571	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 63 associations by consensus.

4E-BP1 by LRRTM4 expression — UCEC

Explore this box plot interactively →