LRRTM4

Across TCGA pan-cancer cohorts, LRRTM4 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of LRRTM4’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where LRRTM4 RNA is repressed in tumor relative to normal tissue. In most cancer types LRRTM4 is over-expressed in tumor, although a few such as LUAD and BRCA show the opposite, repressed pattern.

LUAD, KIRC, and BRCA are the cancer types where LRRTM4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LRRTM4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	II,III,IV	−0.619	<.001	7	view →
KIRC	All	All	+0.346	<.001	6	view →
BRCA	All	III,IV	−0.208	<.001	6	view →
KIRP	All	All	+0.471	.003	4	view →
COAD	Male	II,III,IV	−0.185	<.001	4	view →
LUSC	All	III,IV	−0.726	<.001	3	view →
KICH	Female	III,IV	−0.150	<.001	3	view →
READ	All	All	−0.381	.007	2	view →
UCEC	All	All	−0.287	.020	2	view →
LIHC	Female	II,III,IV	−0.201	.017	2	view →
STAD	All	All	−0.141	.018	2	view →
THCA	Male	IV	−0.020	.025	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

LRRTM4–LUAD

Open the LUAD breakdown →