LRRTM4

Across TCGA cell cohorts, LRRTM4 RNA expression is significantly associated with the go_rna of many other GO terms, with 750 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible LRRTM4-associated GO terms across cancer lineages are Formaldehyde metabolic process, Negative regulation of T-helper 1 type immune response, and DNA conformation change. Each is linked with LRRTM4 in more than 4 cancer types. Because this analysis shows association rather than direction, both LRRTM4-to-partner and partner-to-LRRTM4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Formaldehyde metabolic process grouped by LRRTM4-low versus LRRTM4-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRTM4→partner) and Y-score (partner→LRRTM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Formaldehyde metabolic process →	+0.111	+0.077	<.001	<.001	3	5
LUNG_SCLC	Negative regulation of T-helper 1 type immune response →	-0.781	-0.811	.009	.002	3	5
LUNG_NSCLC_LUSC	DNA conformation change →	+0.067	+0.207	.009	.008	3	4
UPPER_AERODIGESTIVE_TRACT	Post-Golgi vesicle-mediated transport →	+0.048	+0.181	.007	.007	3	4
UPPER_AERODIGESTIVE_TRACT	Response to amino acid starvation →	+0.039	+0.135	.004	.005	3	4
SKIN	Regulation of TORC1 signaling →	+0.036	+0.748	<.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 750 associations by consensus.

Formaldehyde metabolic process by LRRTM4 expression — LARGE_INTESTINE

Explore this box plot interactively →